Oxycodone comes as a solution (liquid), a concentrated solution, a tablet, a capsule, an extended-release (long-acting) tablet (Oxycontin) and an extended-release capsule (Xtampza ER) to take by mouth. The solution, concentrated solution, tablet, and capsule are taken usually with or without food every 4 to 6 hours, either as needed for pain or as regularly scheduled medications. The extended-release tablets (Oxycontin) are taken every 12 hours with or without food. The extended-release capsules (Xtampza ER) are taken every 12 hours with food; eat the same amount of food with each dose. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take oxycodone exactly as directed.

If you are taking Oxaydo brand tablets, swallow the tablets one at a time with plenty of water. Swallow the tablet or right after putting it in your mouth. Do not presoak, wet, or lick the tablets before you put them in your mouth. Do not chew or crush Oxaydo brand tablets. and do not give them through a nasogastric tube (NG tube; a tube threaded through the nose to deliver food and medication directly to the stomach).

If you have trouble swallowing extended-release capsules (Xtampza ER), you can carefully open the capsule and sprinkle the contents on soft foods such as applesauce, pudding, yogurt, ice cream, or jam, then consume the mixture immediately. Dispose of the empty capsule shells right away by flushing them down a toilet. Do not store the mixture for future use.

What are the Side Effects of Oxycodone Withdrawal?

Oxycodone withdrawal is both physical and emotional in nature, and it can range in severity based on how physically dependent a person is on the drug. Physical dependence is related to how much oxycodone a person takes regularly and how long they have been doing so.

Higher doses more often mean a more significant level of dependence and, therefore, more intense withdrawal side effects. Biological and environmental factors coupled with any polydrug use or co-occurring disorders can also contribute to physical dependence and withdrawal.

The withdrawal timeline for oxycodone typically looks like this:

• Within 12 hours or so of taking the drug, physical side effects and mood swings can begin.
• Withdrawal side effects generally peak in two to three days of the last dose.
• Acute withdrawal lasts about five to seven days on average, with symptoms starting to lessen in severity after the first few days.
• Emotional symptoms, cognitive issues, cravings, and sleep disturbances can persist for a few weeks to months during protracted withdrawal.

The formulation of the oxycodone product will determine how long the drug stays in the system and how long it will take to wear off, and, therefore, how long it takes for withdrawal symptoms to begin. For example, extended-release OxyContin remains active for at least 12 hours, while immediate-release Roxicodone is intended to remain active in the bloodstream for four to six hours.

The withdrawal timeline and the significance of the symptoms are influenced by the environment, biology, genetics, and behavioral aspects, making it highly personal and different for everyone.

Withdrawal side effects of oxycodone can include the following:

Withdrawal Side Effects Of Oxycodone

•  Irritability
•  Restlessness
•  Dilated pupils
•  Chills and sweats
•  Nausea and vomiting
•  Diarrhea
•  Stomach cramps
•  Muscle and joint aches
•  Increased sensitivity to pain
•  Insomnia
•  Headache
•  Yawning
•  Watery eyes
•  Runny nose
•  Increased heart rate and blood pressure
•  Loss of appetite
•  Anxiety
•  Depression
•  Mental confusion and clarity issues
•  Cravings